Tebbe B, Gollnick H, Müller R, Reupke H J, Orfanos C E
Universitäts-Hautklinik, Klinikum Steglitz, Freien Universität Berlin.
Hautarzt. 1993 Oct;44(10):647-52.
Gonosomal aberrations such as Turner's syndrome are frequently associated with autoimmune diseases or with serological markers for autoimmune diseases. An autoimmune origin has been suggested for alopecia areata. The simultaneous occurrence of alopecia areata and Turner's syndrome has not formerly been reported. We present here four female patients with Turner's syndrome, who also developed typical alopecia areata. In three of these cases alopecia areata first appeared during adolescence, whilst the fourth patient showed an early manifestation at the age of 10. Two of the patients had alopecia areata of the ophiasis type, while the condition was localized in one and diffuse in the fourth. In addition, two of the patients had diffuse hypotrichosis of the scalp and reduced sweat gland activity, with no other signs of ectodermal dysplasia. The third patient had not develop body hair after her childhood, except for some sparse thin hair in the axilla and in the genital area. The coincidence of alopecia areata and Turner's syndrome may indicate some genetic relationship between the two entities.
性染色体畸变，如特纳综合征，常与自身免疫性疾病或自身免疫性疾病的血清学标志物相关。斑秃被认为有自身免疫起源。此前尚未报道过斑秃与特纳综合征同时出现的情况。我们在此报告4例特纳综合征女性患者，她们也出现了典型的斑秃。其中3例斑秃首次出现在青春期，而第4例患者在10岁时就出现了早期表现。2例患者为ophiasis型斑秃，1例病情局限，第4例为弥漫性。此外，2例患者头皮弥漫性毛发稀少且汗腺活动减弱，无其他外胚层发育不良的体征。第3例患者童年后未长出体毛，仅腋窝和生殖器区域有一些稀疏的细毛。斑秃与特纳综合征的巧合可能表明这两种疾病之间存在某种遗传关系。
