Kühn R A
Z Gesamte Inn Med. 1976 Feb 1;31(3):57-60.
The classification of the protein bodies which Apitz in his time called paraproteins into the large spectre of the immunoglobulins has had a decisive influence on the clinical valency of these findings. Nowadays it is possible to estimate these proteins from the point of view of their development as the functional evidence of a monoclonal proliferation as well as issuing from the part of their immunological effect. 218 cases of monoclonal immunoglobulin are distributed according to the clinical diagnosis. Here it is shown that also a not unconsiderable proportion of benign diseases reveals these findings. Monoclonal immunoglobulins are of special interest when diseases of the group of nosological forms of the lympho-plasma-cellular reticulum and particularly of the paraproteinaemic haemoblastoses are in question. The analysis of the monoclonal macroglobulinaemias has led to a new orientation concerning Waldenstroem's disease which absolutely might be regarded as a nosological entity and no more as a morphological one. A special quality of the protein, the formation of cryoprotein, has close structural relations to the easy chain type kappa, which possibly in general must closely be correlated with reactions of immunoglobulins dependent on temperature.
阿皮茨在当时将蛋白体称为副蛋白，如今将其归类于免疫球蛋白这一庞大范畴，这对这些发现的临床价值产生了决定性影响。如今，从其作为单克隆增殖功能证据的发展角度以及从其免疫效应部分出发，能够对这些蛋白质进行评估。218例单克隆免疫球蛋白病例依据临床诊断进行了分类。结果显示，相当一部分良性疾病也呈现出这些发现。当涉及淋巴浆细胞网状组织疾病组，尤其是副蛋白血症性成血病时，单克隆免疫球蛋白具有特殊意义。对单克隆巨球蛋白血症的分析为瓦尔登斯特伦病带来了新的认识方向，它绝对可被视为一种病种实体，而不再仅仅是一种形态学上的实体。该蛋白质的一种特殊性质，即冷球蛋白的形成，与轻链型κ有着密切的结构关系，这可能总体上必定与依赖温度的免疫球蛋白反应密切相关。
