[Morphological findings after Busulfan long term therapy (author's transl)].

Autopsy findings from two patients who have been treated for several years with Busulfan because of chronic myelogenous leukemia are reported. Beside a pulmonary fibrosis epithelial dysplasias in the respiratory tract, the liver and kidney were detected. Furthermore, in one case beside a proliferation of reticulate cells in the spleen a distinct plasmocytosis of the bone marrow and a so-called "wasting syndrome" were found. The pathogenesis of these changes is still unkown; it may be that immunological processes play a role.