角鲨他汀类化合物，一种茎点霉属真菌产生的新型鲨烯合酶抑制剂。IV. 通过定向生物合成制备氟化角鲨他汀类化合物。
The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.
作者信息
Cannell R J, Dawson M J, Hale R S, Hall R M, Noble D, Lynn S, Taylor N L
机构信息
Department of Natural Products Discovery, Research Limited, Middlesex, U.K.
出版信息
J Antibiot (Tokyo). 1993 Sep;46(9):1381-9. doi: 10.7164/antibiotics.46.1381.
PMID:8226317
Abstract
Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.
摘要
将氟化苯甲酸添加到一种茎点霉属真菌的发酵培养物中，导致了一系列新型氟化角鲨烯合酶抑制剂的生物合成。本文报道了这些化合物的添加研究、分离、结构解析及生物活性。
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