Leyden J J, Kligman A M
Arch Dermatol. 1975 Aug;111(8):1004-10.
Various aluminum salts were evaluated for in vitro and in vivo antimicrobial activity and ability to bind with serum proteins (astrigency) with the object of finding a colorless substance to substitute for carbol-fuchsin solution (Castellani paint) in the treatment of symptomatic interdigital athlete's foot. Aluminum chlorohydrate was more powerful in killing bacteria and fungi than aluminum acetate and aluminum chloride. However, aluminum chloride showed pronounced astringency and was the only compound to bring about rapid resolution of the signs and symptoms of athlete's foot in open-ended clinical trials. This salt promptly controls odor, pruritus, and maceration. The beneficial effect depends largely on drying the surface, not killing organisms. A solution of 30% aluminum chloride was found to be equlvalent to carbol-fuchsin solution in effectively treating symptomatic athlete's foot.
对多种铝盐进行了体外和体内抗菌活性以及与血清蛋白结合能力（收敛性）的评估，目的是寻找一种无色物质来替代石炭酸品红溶液（ Castellani 漆）用于治疗症状性指间足癣。碱式氯化铝在杀灭细菌和真菌方面比醋酸铝和氯化铝更强。然而，氯化铝表现出明显的收敛性，并且是在开放性临床试验中唯一能使足癣体征和症状迅速消退的化合物。这种盐能迅速控制气味、瘙痒和浸渍。其有益效果在很大程度上取决于使表面干燥，而非杀灭微生物。发现 30% 的氯化铝溶液在有效治疗症状性足癣方面与石炭酸品红溶液相当。
