Dean C, Kampine J P
Department of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee.
J Auton Nerv Syst. 1993 Aug-Sep;44(2-3):207-15. doi: 10.1016/0165-1838(93)90033-q.
The role of serotonin (5-HT) in the elaboration of patterns of regional sympathetic discharge evoked from the ventral medulla was examined in cats under Saffan anesthesia. A differential response pattern consisting of an increase in renal sympathetic nerve activity simultaneous with no change in activity to skeletal muscle vasculature was evoked from a group of ventral medullary neurons by microinjection of D,L-homocysteic acid. Subsequent intrathecal administration of the 5-HT receptor antagonist methysergide (200 micrograms) attenuated or abolished the excitatory response to the kidney on restimulation of the medulla, without affecting sympathetic activity to muscle. Methysergide did not affect an excitatory response evoked in the outflow to both the kidney and skeletal muscle vasculature from an adjacent region of the ventral medulla. These results indicate a role for 5-HT in the elaboration of a specific differential pattern of sympathetic response evoked from medullary neurons.
在使用萨芬麻醉的猫身上，研究了血清素（5-羟色胺，5-HT）在延髓腹侧诱发的局部交感神经放电模式形成中的作用。通过微量注射D，L-高胱氨酸，从一组延髓腹侧神经元诱发了一种差异反应模式，即肾交感神经活动增加，同时对骨骼肌血管的活动没有变化。随后鞘内注射5-HT受体拮抗剂麦角酰二乙胺（200微克），在再次刺激延髓时减弱或消除了对肾脏的兴奋性反应，而不影响对肌肉的交感神经活动。麦角酰二乙胺不影响从延髓腹侧相邻区域诱发的对肾脏和骨骼肌血管的兴奋性反应。这些结果表明5-HT在延髓神经元诱发的特定交感反应差异模式的形成中起作用。
