Maria B L, Eskin T A, Quisling R G
Pediatric Neuro-Oncology Program, University of Florida College of Medicine, Gainesville.
J Child Neurol. 1993 Oct;8(4):292-305. doi: 10.1177/088307389300800402.
Gliomas that arise in the brain stem and other malignant gliomas constitute approximately 60% of all brain tumors and have eluded effective therapy, in part because they are able to infiltrate the normal brain. Histopathologic studies have confirmed the presence of infiltrating tumor cells very distant from the glioma mass. We review the neuroimaging and pathologic features of glioma-cell infiltration and some of the complex cellular and biochemical determinants of tumor-cell motility and invasiveness. Understanding how glioma cells become motile and invasive is pivotal to therapeutically targeting the machinery that enables gliomas to infiltrate the brain.
起源于脑干的胶质瘤和其他恶性胶质瘤约占所有脑肿瘤的60%，且一直缺乏有效的治疗方法，部分原因是它们能够浸润正常脑组织。组织病理学研究已证实在远离胶质瘤肿块的部位存在浸润性肿瘤细胞。我们综述了胶质瘤细胞浸润的神经影像学和病理学特征，以及肿瘤细胞运动性和侵袭性的一些复杂细胞和生化决定因素。了解胶质瘤细胞如何变得具有运动性和侵袭性对于靶向治疗使胶质瘤能够浸润大脑的机制至关重要。
