针对奇异变形杆菌的口服疫苗接种。
Oral vaccination against Porteus mirabilis.
作者信息
Jones R J
出版信息
Br J Exp Pathol. 1976 Aug;57(4):395-9.
Abstract
Mice given a single dose of proteus vaccine orally were protected against 1 MLD (minimum lethal dose) of autologous Proteus mirabilis by the fourth day after vaccination. Three doses of oral vaccine induced protection against 1 MLD autologous challenge for 7 days after vaccination and partial protection for a further 8 weeks. Cross-protection against different strains of Pr. mirabilis and against some strains of Pseudomonas aeruginosa, Serratia marcescens and Providencia species was found in mice immunized orally on three consecutive days with a bivalent proteus vaccine.
摘要
口服单剂量变形杆菌疫苗的小鼠在接种疫苗后第四天可抵御1个自源奇异变形杆菌最小致死剂量（MLD）。三剂口服疫苗在接种后7天可诱导抵御1个自源MLD攻击的保护作用，并在接下来的8周内提供部分保护。连续三天口服二价变形杆菌疫苗免疫的小鼠中发现了针对不同奇异变形杆菌菌株以及一些铜绿假单胞菌、粘质沙雷氏菌和普罗威登斯菌属菌株的交叉保护作用。
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本文引用的文献
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Antiserum and antibiotic in the prophylaxis of burns against Pseudomonas aeruginosa.抗血清和抗生素在预防烧伤患者感染铜绿假单胞菌中的应用
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