• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Deficiencies in the National Institute of Health's guidelines for the care and protection of laboratory animals.

作者信息

Stephenson W

机构信息

Department of Philosophy, Lewins and Clark College, Portland, OR 97219.

出版信息

J Med Philos. 1993 Aug;18(4):375-88. doi: 10.1093/jmp/18.4.375.

DOI:10.1093/jmp/18.4.375
PMID:8228684
Abstract

This paper is a critique of NIH guidelines for the care and protection of laboratory animals. It exposes four serious deficiencies in these guidelines: (1) failure to make it clear that the mere pursuit of knowledge does not justify using animals; (2) failure to give any guidance concerning what constitutes human benefit or well-being; (3) failure to countenance trade-offs between human benefit or well-being and animal well-being; (4) failure to clearly specify what constitutes keeping animals in an 'environment appropriate to the species and its life history.' It concludes with the suggestion that the construction and revision of these guidelines is too important to be left to the professionals.

摘要

相似文献

1
Deficiencies in the National Institute of Health's guidelines for the care and protection of laboratory animals.
J Med Philos. 1993 Aug;18(4):375-88. doi: 10.1093/jmp/18.4.375.
2
The protection of laboratory animals: a response to Stephenson.实验室动物的保护:对斯蒂芬森的回应
J Med Philos. 1994 Aug;19(4):389-94. doi: 10.1093/jmp/19.4.389.
3
Economic perspectives on bioethics.
J Med Philos. 1993 Aug;18(4):389-97. doi: 10.1093/jmp/18.4.389.
4
Institutional animal care and use committees and the moderate position.机构动物护理和使用委员会与温和立场。
Between Species. 1991 Winter;7(1):6-8. doi: 10.15368/bts.1991v7n1.2.
5
Animal rights and wrongs.动物的是非曲直。
Healthscan. 1984 Nov-Dec;1(3):3-10.
6
Animal research: a call for legislative reform requiring ethical merit review.动物研究:呼吁进行立法改革,要求进行伦理价值审查。
HELR Harvard Environ Law Rev. 1989;13(2):423-84.
7
The use of nonhuman animals in speech, language, and hearing research.
ASHA. 1993 Apr;35(4):57-65.
8
Animal advisors forced into the open.动物顾问被迫公开露面。
New Sci. 1997 Jan 25;153(2066):9.
9
Of mice and medicine: balancing scientific needs and animal welfare.小鼠与医学:平衡科学需求与动物福利
Washington Post. 1985 Sep 11:Health Su-15.
10
Groups sue to tighten oversight of rodents.多个团体起诉要求加强对啮齿动物的监管。
Science. 1999 Feb 5;283(5403):767, 769.

引用本文的文献

1
Enhancing doxorubicin's anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor.通过使用组蛋白去乙酰化酶(HDAC)抑制剂靶向Akt/Gsk3β/mTOR-SREBP1信号轴增强阿霉素对结直肠癌的抗癌作用。
Korean J Physiol Pharmacol. 2025 May 1;29(3):321-335. doi: 10.4196/kjpp.24.274.
2
Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway.熊果酸和阿霉素通过靶向 Akt 信号通路和激活 Hippo 信号通路抑制结直肠肿瘤发生。
Mol Med Rep. 2023 Jan;27(1). doi: 10.3892/mmr.2022.12898. Epub 2022 Nov 16.
3
Ketamine administration ameliorates anesthesia and surgery-induced cognitive dysfunction via activation of TRPV4 channel opening.
氯胺酮给药通过激活瞬时受体电位香草酸亚型4(TRPV4)通道开放改善麻醉和手术引起的认知功能障碍。
Exp Ther Med. 2022 Jun 1;24(1):478. doi: 10.3892/etm.2022.11405. eCollection 2022 Jul.
4
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.抑制ACAT-1表达对Lewis肺癌生长和转移的影响。
Oncol Lett. 2019 Aug;18(2):1548-1556. doi: 10.3892/ol.2019.10427. Epub 2019 May 31.
5
Downregulation of G‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis.海马中 G 蛋白偶联受体 30 的下调减弱了雌激素在关键期假说中的神经保护作用。
Mol Med Rep. 2018 Apr;17(4):5716-5725. doi: 10.3892/mmr.2018.8618. Epub 2018 Feb 16.
6
Decision Making and the IACUC: Part 1- Protocol Information Discussed at Full-Committee Reviews.决策与机构动物护理和使用委员会:第1部分——全委会审查中讨论的方案信息
J Am Assoc Lab Anim Sci. 2015 Jul;54(4):389-98.
7
Intrathecal injection of fluorocitric acid inhibits the activation of glial cells causing reduced mirror pain in rats.鞘内注射氟柠檬酸可抑制胶质细胞的激活,从而减轻大鼠的镜像痛。
BMC Anesthesiol. 2014 Dec 15;14:119. doi: 10.1186/1471-2253-14-119. eCollection 2014.