Muraskas J K, Husain A, Myers T F, Anderson C L, Black P R
Division of Neonatology, Loyola University Medical Center, Maywood, IL 60153.
J Pediatr Surg. 1993 Aug;28(8):999-1002. doi: 10.1016/0022-3468(93)90501-b.
During a period of 5 years, 33 newborns with congenital diaphragmatic hernia were treated. Three groups presenting with respiratory distress in the delivery room were identified. These included 8 newborns with agenesis (group 1) and 4 newborns with nonagenesis (group 2), all of whom died. There were 19 nonagenesis survivors (group 3), giving an overall survival rate of 61%. Two newborns who presented beyond 6 hours of life were excluded. No one specific arterial blood gas value or ventilation parameter obtained preoperatively could predict survival. Postmortem right and left lung weights, lung/body weight ratio, and radial alveolar counts demonstrate that agenesis is a unique subgroup with profound pulmonary hypoplasia and a dismal prognosis.
在5年期间，对33例先天性膈疝新生儿进行了治疗。确定了三组在产房出现呼吸窘迫的患儿。其中包括8例肺不发育患儿（第1组）和4例肺发育不全患儿（第2组），所有这些患儿均死亡。有19例肺发育不全幸存者（第3组），总生存率为61%。2例出生后6小时以上出现症状的新生儿被排除。术前获得的任何一项特定动脉血气值或通气参数均无法预测生存情况。尸检时右肺和左肺重量、肺/体重比以及肺泡计数显示，肺不发育是一个独特的亚组，伴有严重的肺发育不全且预后不良。
