3-（烷基氨基）-4H-吡啶并[4,3-e]-1,2,4-噻二嗪1,1-二氧化物作为大鼠胰腺β细胞胰岛素释放的强效抑制剂：一类新型钾通道开放剂？ - Suppr

Suppr

超能文献

3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

作者信息

Pirotte B, de Tullio P, Lebrun P, Antoine M H, Fontaine J, Masereel B, Schynts M, Dupont L, Herchuelz A, Delarge J

机构信息

Laboratoire de Chimie Pharmaceutique, Université de Liège, Belgium.

出版信息

J Med Chem. 1993 Oct 15;36(21):3211-3. doi: 10.1021/jm00073a025.

DOI:10.1021/jm00073a025

PMID:8230110

Abstract

摘要

相似文献

3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?3-（烷基氨基）-4H-吡啶并[4,3-e]-1,2,4-噻二嗪1,1-二氧化物作为大鼠胰腺β细胞胰岛素释放的强效抑制剂：一类新型钾通道开放剂？

J Med Chem. 1993 Oct 15;36(21):3211-3. doi: 10.1021/jm00073a025.

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.结构上与二氮嗪和匹那地尔相关的 3-烷基氨基-4H-吡啶并[2,3-e]-1,2,4-噻二嗪 1,1-二氧化物作为作用于血管平滑肌细胞的钾通道开放剂：设计、合成及药理学评价

J Med Chem. 2000 Apr 20;43(8):1456-66. doi: 10.1021/jm991069o.

3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.作为钾通道开放剂的3-和4-取代的4H-吡啶并[4,3-e]-1,2,4-噻二嗪1,1-二氧化物：合成、药理学评价及构效关系

J Med Chem. 1996 Feb 16;39(4):937-48. doi: 10.1021/jm9500582.

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.与二氮嗪和环噻嗪化学相关的4H-1,2,4-吡啶并噻二嗪1,1-二氧化物和2,3-二氢-4H-1,2,4-吡啶并噻二嗪1,1-二氧化物作为(R/S)-2-氨基-3-(3-羟基-5-甲基异恶唑-4-基)丙酸受体的强效正变构调节剂：设计、合成、药理学及构效关系

J Med Chem. 1998 Jul 30;41(16):2946-59. doi: 10.1021/jm970694v.

Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2-butylamino)-4H- and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers.两种组织选择性ATP敏感性钾通道开放剂——3-(2-丁基氨基)-4H-吡啶并[4,3-e]-1,2,4-噻二嗪1,1-二氧化物和3-(3-甲基-2-丁基氨基)-4H-吡啶并[4,3-e]-1,2,4-噻二嗪1,1-二氧化物的R-和S-对映体的制备及药理学评价

Bioorg Med Chem. 1999 Aug;7(8):1513-20. doi: 10.1016/s0968-0896(99)00082-6.

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.6-氯-3-烷基氨基-4H-噻吩并[3,2-e]-1,2,4-噻二嗪1,1-二氧化物衍生物能有效且选择性地激活胰腺β细胞的ATP敏感性钾通道。

J Med Chem. 2002 Sep 12;45(19):4171-87. doi: 10.1021/jm0208121.

2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?2-烷基-3-烷基氨基-2H-苯并和吡啶并噻二嗪1,1-二氧化物：从钾离子ATP通道开放剂到钙离子通道阻滞剂？

Biol Chem. 2002 Nov;383(11):1759-68. doi: 10.1515/BC.2002.197.

Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.

J Med Chem. 2006 Nov 16;49(23):6779-88. doi: 10.1021/jm060534w.

New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.新型3-烷基氨基-4H-噻吩并[1,2,4]噻二嗪1,1-二氧化物衍生物可激活胰腺β细胞的ATP敏感性钾通道。

J Med Chem. 2006 Jul 13;49(14):4127-39. doi: 10.1021/jm060042j.

Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.靶向组织选择性胰腺β细胞的钾离子通道开放剂，属于3-烷基氨基-7-卤代-4H-1,2,4-苯并噻二嗪1,1-二氧化物。

J Med Chem. 2003 Jul 17;46(15):3342-53. doi: 10.1021/jm021117w.

引用本文的文献

Synthesis and biological activity of novel 3-heteroaryl-2-pyrido[4,3-][1,2,4]thiadiazine and 3-heteroaryl-2-benzo[][1,2,4]thiadiazine 1,1-dioxides.新型3-杂芳基-2-吡啶并[4,3-][1,2,4]噻二嗪和3-杂芳基-2-苯并[][1,2,4]噻二嗪1,1-二氧化物的合成及生物活性

Monatsh Chem. 2013;144(8):1197-1203. doi: 10.1007/s00706-013-0988-5. Epub 2013 May 14.

Regioselective synthesis of novel N2- and N4-substituted 7-methylpyrazolo[4,5-e][1,2,4]thiadiazines.新型N2-和N4-取代的7-甲基吡唑并[4,5-e][1,2,4]噻二嗪的区域选择性合成。

Molecules. 2006 Nov 1;11(11):827-36. doi: 10.3390/11110827.

Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.婴儿持续性高胰岛素血症性低血糖症的治疗。了解β细胞对二氮嗪和生长抑素的反应性。

J Clin Invest. 1997 Oct 1;100(7):1888-93. doi: 10.1172/JCI119718.

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets.

Experientia. 1994 Sep 15;50(9):830-2. doi: 10.1007/BF01956464.

Pharmacology of the potassium channel openers.钾通道开放剂的药理学

Cardiovasc Drugs Ther. 1995 Mar;9 Suppl 2:185-93. doi: 10.1007/BF00878465.

Effects of BRL55834 in rat portal vein and bovine trachea: evidence for the induction of a glibenclamide-resistant, ATP-sensitive potassium current.BRL55834对大鼠门静脉和牛气管的作用：诱导格列本脲抵抗性ATP敏感性钾电流的证据。

Br J Pharmacol. 1995 Jul;115(6):1027-37. doi: 10.1111/j.1476-5381.1995.tb15914.x.

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