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配给失败。稀缺重要器官再次移植的伦理教训。

Rationing failure. The ethical lessons of the retransplantation of scarce vital organs.

作者信息

Ubel P A, Arnold R M, Caplan A L

机构信息

Department of Medicine, University of Pittsburgh, PA 15261.

出版信息

JAMA. 1993 Nov 24;270(20):2469-74. doi: 10.1001/jama.270.20.2469.

Abstract

Because of a shortage of transplantable livers and hearts, the transplant community has had to decide--by who gets an organ--who lives or dies. Despite this shortage, whether one has previously received a transplant is not used as a criterion to distribute organs. The existing allocation system distributes 10% to 20% of available hearts and livers to retransplant patients. This article examines three differences between primary transplantation and retransplantation that may affect the priority that retransplant candidates should receive in vying for organs: (1) the special obligations that transplant teams have not to abandon patients on whom they have already performed a transplant, (2) the fairness of allowing individuals to get multiple transplants while some die awaiting their first, and (3) the difference in efficacy between primary transplantation and retransplantation. Only this last difference holds up to critical analysis. Our moral duty to direct scarce, lifesaving resources to those likely to benefit from them, suggests that, all other things equal, primary transplant candidates should receive priority because their mortality after transplantation is lower. Consistency also demands that previous transplant history be taken into account, as we already allocate organs according to ABO blood group matching, a factor that affects transplant outcome approximately the same amount as a previous transplantation. We therefore conclude that the system should be revised so that primary transplant candidates have a better chance of receiving organs than retransplant candidates.

摘要

由于可用于移植的肝脏和心脏短缺,移植界不得不通过决定谁能获得器官来决定谁生谁死。尽管存在这种短缺,但一个人之前是否接受过移植并未被用作分配器官的标准。现有的分配系统将10%至20%的可用心脏和肝脏分配给再次移植的患者。本文探讨了初次移植和再次移植之间可能影响再次移植候选人在争夺器官时应获得的优先级的三个差异:(1)移植团队不抛弃他们已经进行过移植的患者的特殊义务,(2)允许个人进行多次移植而一些人在等待首次移植时死亡的公平性,以及(3)初次移植和再次移植之间的疗效差异。只有最后一个差异经得起批判性分析。我们将稀缺的救命资源导向那些可能从中受益的人的道德责任表明,在其他条件相同的情况下,初次移植候选人应获得优先考虑,因为他们移植后的死亡率较低。一致性还要求考虑先前的移植历史,因为我们已经根据ABO血型匹配来分配器官,这一因素对移植结果的影响与先前的移植大致相同。因此,我们得出结论,该系统应进行修订,以使初次移植候选人比再次移植候选人有更好的机会获得器官。

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