Inoue Y, Nakazawa K, Hikawa Y, Saitoh Y, Yasuda K
Department of Anesthesia, Tokyo Metropolitan Hospital of Fuchu.
Masui. 1993 Sep;42(9):1338-42.
The effects of cervical epidural morphine and buprenorphine on postoperative pain were studied in 12 patients who received thoracic surgery twice. The patients who had received morphine 3 mg on the first operation were given buprenorphine 0.15 mg on the second operation, and the others received them vice versa. Morphine or buprenorphine was administered with 6 ml of 0.25% bupivacaine before skin incision. The duration of pain relief with morphine was longer (21.5 +/- 4.0 h) than with buprenorphine (13.9 +/- 7.8 h). The result of the questionnaires to the patients after operation shows that 10 patients (84%) were satisfied with morphine whereas only 6 patients (50%) were satisfied with buprenorphine. Seven patients preferred morphine to buprenorphine for postoperative analgesia, and the rest of the patients stated that analgesic effects were similar between the two. It seems that epidural morphine 3 mg may give more excellent postoperative pain relief after the thoracic surgery than epidural buprenorphine 0.15 mg.
对12例接受两次胸外科手术的患者研究了颈段硬膜外给予吗啡和丁丙诺啡对术后疼痛的影响。第一次手术接受3毫克吗啡的患者在第二次手术时给予0.15毫克丁丙诺啡，其他患者则相反。在皮肤切口前，将吗啡或丁丙诺啡与6毫升0.25%布比卡因一起给药。吗啡的镇痛持续时间（21.5±4.0小时）比丁丙诺啡（13.9±7.8小时）长。术后对患者的问卷调查结果显示，10例患者（84%）对吗啡满意，而只有6例患者（50%）对丁丙诺啡满意。7例患者术后镇痛更喜欢吗啡而非丁丙诺啡，其余患者表示两者的镇痛效果相似。似乎胸段手术后，3毫克硬膜外吗啡比0.15毫克硬膜外丁丙诺啡能提供更优的术后疼痛缓解。
