狒狒大脑中胆碱乙酰转移酶和乙酰胆碱酯酶活性的区域分布。

Regional distribution of choline acetyltransferase and acetylcholinesterase activity in baboon brain.

作者信息

Nakamura Y, Hassler R, Kataoka K, Bak I J, Kim J S

出版信息

Folia Psychiatr Neurol Jpn. 1976;30(2):185-94. doi: 10.1111/j.1440-1819.1976.tb00121.x.

DOI:10.1111/j.1440-1819.1976.tb00121.x

Abstract

(1) The activities of choline acetyltransferase (ChAc) (EC 2.3.1.6) and acetylcholinesterase (AChE) (EC 3.1.1.7) were determined in about one hundred regions and subregions of baboon brain. The activities and distributions of these enzymes were in comparable to those found previously in the brains of other species. (2) ChAc activity was highest in the interpeduncular nucleus, where it was about twice that in the putamen, the region previously thought to be the richest in this enzyme. The caudate nucleus, the substantia perforata, the nucleus basalis, the central part of the amygdala and the oculomotor nucleus also had high activities. The activities in the cerebral and cerebellar cortex were less than one twentieth of that in the interpeduncular nucleus. (3) The distribution of AChE activity was not entirely in parallel with that of ChAc.

摘要

(1) 在狒狒大脑约100个区域和亚区域中测定了胆碱乙酰转移酶（ChAc）（EC 2.3.1.6）和乙酰胆碱酯酶（AChE）（EC 3.1.1.7）的活性。这些酶的活性和分布与先前在其他物种大脑中发现的情况相当。(2) ChAc活性在脚间核中最高，约为壳核中活性的两倍，壳核是先前认为该酶含量最丰富的区域。尾状核、穿质、基底核、杏仁核中央部分和动眼神经核也有较高活性。大脑和小脑皮质中的活性不到脚间核中活性的二十分之一。(3) AChE活性的分布与ChAc的分布并不完全平行。