胆碱乙酰转移酶在人脑内的区域分布：亨廷顿舞蹈病中的变化
Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea.
作者信息
Aquilonius S M, Eckernås S A, Sundwall A
出版信息
J Neurol Neurosurg Psychiatry. 1975 Jul;38(7):669-77. doi: 10.1136/jnnp.38.7.669.
A stereotaxic method of tissue sampling has been developed permitting detailed studies of the distribution of choline acetyltransferase (CAT) in brains from controls and from patients suffering from Huntington's chorea. The characteristic pattern of CAT distribution within extra-pyramidal structures is described. In Huntington's chorea, CAT is unevenly reduced in several brain regions particularly in the rostromedial part of the caudate nucleus. The results indicate a preferential degeneration of neostriatal cholinergic neurones in Huntington's chorea.
已开发出一种立体定位组织采样方法，可对对照组和患有亨廷顿舞蹈症患者大脑中胆碱乙酰转移酶（CAT）的分布进行详细研究。本文描述了锥体外结构内CAT分布的特征模式。在亨廷顿舞蹈症中，CAT在几个脑区分布不均，尤其在尾状核的吻内侧部分减少。结果表明，亨廷顿舞蹈症中存在新纹状体胆碱能神经元的优先退化。
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