Sasaki T
Second Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
Nihon Jinzo Gakkai Shi. 1993 Sep;35(9):1033-41.
To elucidate the morphological basis of glomerular hematuria in IgA nephropathy, morphometric analysis of GBM alterations was performed by electron microscopy in 73 cases of IgA nephropathy. These cases were divided into 2 groups by the degree of hematuria. The IgA (1) groups (52 cases) showed 1-30 Red Blood Cells (RBC)/hpf in urinary sediment and the IgA (2) group (21 cases) showed 30 or more RBC/hpf. The GBM alterations were observed in 67% of IgA nephropathy patients. Splitting and focal thinning of GBM were more frequent in the IgA (2) group than in the IgA (1) group. The gap was not associated with the degree of hematuria, but when accompanying splitting, it was with the degree of hematuria. It was concluded that most IgA nephropathy patients had GBM alterations, and splitting of the lamina densa, focal thinning of GBM, and a gap with splitting, which was associated with the degree of hematuria.
为阐明IgA肾病肾小球血尿的形态学基础，对73例IgA肾病患者进行了电子显微镜下肾小球基底膜（GBM）改变的形态计量分析。这些病例按血尿程度分为2组。IgA（1）组（52例）尿沉渣中红细胞（RBC）计数为1 - 30个/高倍视野，IgA（2）组（21例）尿沉渣中红细胞计数为30个及以上/高倍视野。67%的IgA肾病患者观察到GBM改变。GBM的分裂和局灶性变薄在IgA（2）组比IgA（1）组更常见。这种间隙与血尿程度无关，但当伴有分裂时，则与血尿程度有关。得出的结论是，大多数IgA肾病患者存在GBM改变，致密层分裂、GBM局灶性变薄以及伴有分裂的间隙与血尿程度有关。
