Terada H, Gomi T, Sasaki K, Murakami S, Sato S, Nagamoto M, Kuwajima A, Hiramatsu Y, Iwabuchi S, Samejima H
Department of Neuroradiology, Tokyo Women's Medical College.
Kaku Igaku. 1993 Sep;30(9):1075-80.
We studied the effect of acetazolamine (DIAMOXR) on vascular response in areas with crossed cerebellar diaschisis (CCD) using consecutive 99mTc-hexamethyl-propyleneamine oxime (HMPAO) SPECT studies before and after DIAMOX administration with a subtraction method. Regions of interest were drawn over the bilateral cerebellar cortices and interhemispheric asymmetry indices (IAI) were obtained. Eleven of 14 patients with CCD at baseline showed decrease of IAI after DIAMOX administration. Although there is a possibility of underestimation of increase in perfusion in unaffected cerebellar hemisphere, this result suggests a greater increase in perfusion in the affected cerebellar hemisphere as compared with in the contralateral unaffected one and suggests more dilatation of the arterioles in areas with CCD post-DIAMOX than in areas without CCD. However nonsignificant correlation between IAI at baseline and difference of IAI from baseline to post-DIAMOX did not support the hypothesis of more dilatation post-DIAMOX of more constricted arterioles.
我们采用连续的99m锝-六甲基丙烯胺肟（HMPAO）单光子发射计算机断层扫描（SPECT）研究，并运用减法方法，在给予乙酰唑胺（醋氮酰胺）前后，研究了乙酰唑胺（醋氮酰胺）对交叉性小脑失联络（CCD）区域血管反应的影响。在双侧小脑皮质上绘制感兴趣区，并获得半球间不对称指数（IAI）。14例基线时患有CCD的患者中，有11例在给予醋氮酰胺后IAI降低。尽管存在低估未受影响小脑半球灌注增加的可能性，但该结果表明，与对侧未受影响的半球相比，受影响的小脑半球灌注增加更大，并且表明醋氮酰胺给药后CCD区域的小动脉比无CCD区域的小动脉扩张更明显。然而，基线时的IAI与基线至醋氮酰胺给药后IAI的差异之间无显著相关性，这并不支持醋氮酰胺给药后更收缩的小动脉扩张更明显这一假说。
