Kajita J, Imanishi S, Sako H, Arita M, Hadama T
Department of Physiology, Oita Medical University, Japan.
Jpn J Physiol. 1993;43(3):403-8. doi: 10.2170/jjphysiol.43.403.
In quiescent human atrial muscles obtained from patients with various cardiac diseases, the intracellular Na+ activity (aNai) and the resting membrane potential (Vm) were recorded simultaneously, using double-barreled Na(+)-selective microelectrodes. The Vm averaged -44.1 +/- 5.0 mV and the aNai, 6.9 +/- 1.7 mM under normal Tyrode's solution containing 5.4 mM [K]oi,The aiNa value was within the range of aNai reported in various cardiac tissues from intact animals. Dihydro-ouabain (10(-5) M) significantly increased the aNai and depolarized the Vm. The results suggest that even in these depolarized atrial muscles the aNai remains within physiologic levels and that the Na-K pump may not be impaired. This is the first report to measure the aNai in human atrial muscles.
在从患有各种心脏疾病的患者身上获取的静态人心房肌中，使用双管钠选择性微电极同时记录细胞内钠活性（aNai）和静息膜电位（Vm）。在含有5.4 mM [K]oi的正常台氏液中，Vm平均为-44.1±5.0 mV，aNai为6.9±1.7 mM，aiNa值在完整动物各种心脏组织中报道的aNai范围内。二氢哇巴因（10^(-5) M）显著增加aNai并使Vm去极化。结果表明，即使在这些去极化的心房肌中，aNai仍保持在生理水平，并且钠钾泵可能未受损。这是首次测量人心房肌中aNai的报告。
