Szwed H, Skorykow-Sapińska A, Jasek S, Malczewska B, Wiernikowski A, Sadowski Z
Instytutu Kardiologii, Warszawie.
Kardiol Pol. 1993 Sep;39(9):164-8; discussion 169-71.
To test the sensitivity and specificity of noninvasive tests for detecting myocardial ischemia, 78 patients undergoing cardiac catheterisation for suspected coronary artery disease (CAD) were studied in prospective blinded manner with exercise echocardiography (EE), ecg stress test (ET) and 24-hour Holter monitoring for analysis of ST-segment changes (HM). All noninvasive tests were repeated after one year follow-up period. Exercise was performed in a supine position using a bicycle ergometer. Real time 2-DE examinations were performed in the left lateral position: at rest, at the peak of exercise and immediately after exercise testing. The sensitivity and specificity of EE, ET and HM for detection of CAD were: 76%, 92%; 90%, 48%; and 80%, 71% respectively. In a group of 48 pts with the narrowing of coronary artery (CA) < 50%, the follow-up EE was negative in 45. In a group of 30 pts with significant narrowing of CA, 10 were asymptomatic within one year after PTCA or CABG; in 9 of them the follow-up EE as well as ET were negative. HM less correlated with clinical course in asymptomatic subjects: in 4 patients it was negative and in 6 - positive. The reminding 20 patients with CAD treated medically, with PTCA or CABG were symptomatic after one year. The follow-up EE, ET and HM studies were positive in 17, 19 and 17 cases respectively. We conclude that sensitivity of EE in diagnosis of CAD is comparable to ET and HM, but its specificity is higher.(ABSTRACT TRUNCATED AT 250 WORDS)
为了测试检测心肌缺血的非侵入性检查的敏感性和特异性,我们以前瞻性盲法对78例因疑似冠状动脉疾病(CAD)而接受心导管检查的患者进行了研究,采用运动超声心动图(EE)、心电图负荷试验(ET)和24小时动态心电图监测以分析ST段变化(HM)。在一年的随访期后,重复进行所有非侵入性检查。使用自行车测力计在仰卧位进行运动。在左侧卧位进行实时二维超声心动图检查:静息时、运动峰值时和运动试验后立即检查。EE、ET和HM检测CAD的敏感性和特异性分别为:76%,92%;90%,48%;80%,71%。在一组冠状动脉(CA)狭窄<50%的48例患者中,45例随访EE结果为阴性。在一组CA明显狭窄的30例患者中,10例在接受经皮冠状动脉腔内血管成形术(PTCA)或冠状动脉旁路移植术(CABG)后一年内无症状;其中9例随访EE和ET均为阴性。HM与无症状受试者的临床病程相关性较小:4例为阴性,6例为阳性。其余20例接受药物治疗、PTCA或CABG的CAD患者在一年后出现症状。随访EE、ET和HM检查分别有17例、19例和17例结果为阳性。我们得出结论,EE诊断CAD的敏感性与ET和HM相当,但其特异性更高。(摘要截断于250字)