Lautier D, Lagueux J, Thibodeau J, Ménard L, Poirier G G
Poly(ADP-ribose) Metabolism Laboratory, Molecular Endocrinology, CHUL, Ste-Foy, Québec, Canada.
Mol Cell Biochem. 1993 May 26;122(2):171-93. doi: 10.1007/BF01076101.
In the past five years, poly(ADP-ribosyl)ation has developed greatly with the help of molecular biology and the improvement of biochemical techniques. In this article, we describe the physico-chemical properties of the enzymes responsible for the synthesis and degradation of poly(ADP-ribose), respectively poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase. We then discuss the possible roles of this polymer in DNA repair and replication as well as in cellular differentiation and transformation. Finally, we put forward various hypotheses in order to better define the function of this polymer found only in eucaryotes.
在过去五年中，借助分子生物学和生化技术的改进，聚（ADP - 核糖）化得到了极大的发展。在本文中，我们分别描述了负责聚（ADP - 核糖）合成与降解的酶，即聚（ADP - 核糖）聚合酶和聚（ADP - 核糖）糖苷水解酶的物理化学性质。接着，我们讨论了这种聚合物在DNA修复、复制以及细胞分化和转化中的可能作用。最后，我们提出了各种假设，以便更好地界定这种仅在真核生物中发现的聚合物的功能。
