[High dose methylprednisolone therapy in patients with multiple sclerosis].

A trial of high-dose pulsed intravenous methylprednisolone was carried out in 20 patients with multiple sclerosis (MS). Multimodal evoked potentials examination (visual, brainstem auditory and somatosensory evoked potentials) were evaluated before and after treatment with methylprednisolone (a single daily dose of 1000 mg was administrated for five consecutive days). Clinical improvement did not correlate well with evoked potential changes.