Bartoletti M, Gaiardi M, Gubellini C, Bacchi A, Babbini M
Department of Pharmacology, University of Bologna, Italy.
Neuropharmacology. 1993 Sep;32(9):865-8. doi: 10.1016/0028-3908(93)90141-o.
The effects of buprenorphine (0.01-0.1 mg/kg) on the activity of nondependent and morphine dependent rats (a 20 mg/kg dose for 28 days) were determined. In naive animals buprenorphine exhibited both depressive and stimulatory actions upon the motility of rats, as repeatedly described for morphine. When buprenorphine was administered to rats chronically treated with morphine, the depressive effect disappeared (cross-tolerance to the inhibitory action); on the contrary the excitatory effect was enhanced (cross-sensitization). The results are discussed in terms of cross-sensitization to the excitatory effects in morphine dependent animals as predictor of morphine-like addictive properties in humans.
测定了丁丙诺啡（0.01 - 0.1毫克/千克）对非依赖型和吗啡依赖型大鼠（28天给予20毫克/千克剂量）活动的影响。在未接触过药物的动物中，丁丙诺啡对大鼠的活动表现出抑制和兴奋作用，正如吗啡反复出现的情况那样。当对长期用吗啡处理的大鼠给予丁丙诺啡时，抑制作用消失（对抑制作用产生交叉耐受性）；相反，兴奋作用增强（交叉致敏）。根据对吗啡依赖动物兴奋作用的交叉致敏作为人类吗啡样成瘾特性预测指标这一点对结果进行了讨论。
