Okuma T
National Center of Neurology and Psychiatry, Tokyo, Japan.
Neuropsychobiology. 1993;27(3):138-45. doi: 10.1159/000118969.
Characteristics of the responders and nonresponders to prophylactic treatment with carbamazepine (CBZ) or lithium (Li) were investigated in a retrospective study of 215 bipolar disorder patients who had received more than 2 years of CBZ or Li treatment in Japan. Patients of mania-dominant type, with isolated occurrence of manic and depressive episodes, with onset of the illness below 30 years of age, and with atypical symptomatology, tended to respond favorably to CBZ. Rapid cyclers and patients with a past history of rapid cycling and with a continuous recurrence of episodes responded unfavorably to CBZ. Patients of mania-dominant type also showed a favorable response to Li, while patients with a continuous-type course, with rapid cycling, and a past history of rapid cycling, as with CBZ, tended to respond unfavorably to Li.
在一项针对215名双相情感障碍患者的回顾性研究中，调查了接受卡马西平（CBZ）或锂盐（Li）预防性治疗的有反应者和无反应者的特征。这些患者在日本接受了超过2年的CBZ或Li治疗。以躁狂为主型、仅有躁狂和抑郁发作、发病年龄在30岁以下且有非典型症状的患者，往往对CBZ反应良好。快速循环型患者以及有快速循环既往史且发作持续复发的患者对CBZ反应不佳。以躁狂为主型的患者对Li也表现出良好反应，而病程为持续型、快速循环型以及有快速循环既往史的患者，与对CBZ的反应一样，往往对Li反应不佳。
