Dubovsky S L
University of Colorado School of Medicine, Denver, CO 80262.
Neuropsychobiology. 1993;27(3):184-92. doi: 10.1159/000118978.
Increased free intracellular calcium ion concentration ([Ca2+]i) has been found in lymphocytes and blood platelets of patients with bipolar affective disorders when they are acutely ill, but not after recovery. Because lithium alters intracellular calcium ion dynamics and lowers platelet [Ca2+]i in affectively ill patients but not controls, drugs whose primary action is to modulate [Ca2+]i in hyperactive cells have been used as antimanic agents. The best studied of these is verapamil, a calcium channel blocking agent (CCB) that appears most effective for lithium-responsive patients. Because they interact with different central CCB receptors, second-generation CCBs may have a different spectrum of action. CCBs are usually well tolerated and may be useful for a number of other psychiatric, neurological and medical conditions.
双相情感障碍患者急性发病时，其淋巴细胞和血小板内的游离钙离子浓度（[Ca2+]i）会升高，但康复后则不会。由于锂盐可改变细胞内钙离子动态变化，并降低情感障碍患者而非对照组患者的血小板[Ca2+]i，因此，主要作用是调节活跃细胞内[Ca2+]i的药物已被用作抗躁狂药物。其中研究最多的是维拉帕米，一种钙通道阻滞剂（CCB），对锂盐反应性患者似乎最为有效。由于第二代CCB与不同的中枢CCB受体相互作用，其作用谱可能不同。CCB通常耐受性良好，可能对许多其他精神、神经和医学疾病有用。
