Mraovitch S, Calando Y, Onteniente B, Peschanski M, Seylaz J
Laboratoire de Recherches Cérébrovasculaires (CNRS UA 641), Faculté de Médecine, Université Paris VII, France.
Neurosci Lett. 1993 Jul 23;157(2):140-4. doi: 10.1016/0304-3940(93)90722-w.
Changes in local cerebral blood flow (lCBF) and local cerebral glucose utilization (lCGU) were assessed in dopaminergic primary target areas in the rat 6 weeks after unilateral lesion of dopaminergic neurons within the substantia nigra pars compacta (SNc) and adjacent ventrotegmental area (VTA) using 6-hydroxydopamine (6-OHDA). lCBF and lCGU were determined using the autoradiographic [14C]iodoantipyrine and [14C]2-deoxyglucose method. Dopaminergic deafferentation provoked a marked unilateral lCBF decrease in the dorso-lateral portion of the rostral caudate-putamen. The decrease in lCBF was not associated with significant changes in glucose metabolism. Thus, lesions of dopaminergic afferents to the caudate-putamen appear to provoke a sustained decrease in basal blood flow with unchanged local metabolic activity.
使用6-羟基多巴胺（6-OHDA）对大鼠黑质致密部（SNc）和相邻腹侧被盖区（VTA）内的多巴胺能神经元进行单侧损伤6周后，评估了多巴胺能主要靶区的局部脑血流量（lCBF）和局部脑葡萄糖利用率（lCGU）。使用放射自显影术的[14C]碘安替比林和[14C]2-脱氧葡萄糖方法测定lCBF和lCGU。多巴胺能去传入神经支配引起尾状核-壳核背外侧部分明显的单侧lCBF降低。lCBF的降低与葡萄糖代谢的显著变化无关。因此，尾状核-壳核多巴胺能传入神经的损伤似乎会引起基础血流量的持续降低，而局部代谢活动不变。
