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小鼠海马苔藓纤维突触的精细结构特征是由苔藓纤维轴突的密度决定的吗?

Are the fine-structural characteristics of mouse hippocampal mossy fiber synapses determined by the density of mossy fiber axons?

作者信息

Nek N, Schwegler H, Crusio W E, Frotscher M

机构信息

Institute of Anatomy, University of Freiburg, FRG.

出版信息

Neurosci Lett. 1993 Aug 6;158(1):75-8. doi: 10.1016/0304-3940(93)90616-s.

Abstract

Heritable variation of mossy fiber synapses in hippocampal region CA3 was studied in the two inbred mouse strains C3H and CPB-K. Previous Timm studies had shown a larger mossy fiber projection in C3H mice. In contrast, synaptic boutons of CPB-K mice were larger in size and perimeter and were contacted by more dendritic spines than in C3H mice. These results point to an inverse relationship between the size of the mossy fiber projection and the number of spine synapses formed by an individual mossy fiber bouton. Thus, the fiber density of a projection may be crucial for the actual morphology of the synaptic contacts formed.

摘要

在两个近交系小鼠品系C3H和CPB-K中,研究了海马CA3区苔藓纤维突触的遗传变异。先前的硫堇染色研究表明,C3H小鼠的苔藓纤维投射更大。相比之下,CPB-K小鼠的突触小体在大小和周长上更大,并且与C3H小鼠相比,有更多的树突棘与之接触。这些结果表明,苔藓纤维投射的大小与单个苔藓纤维突触小体形成的棘突触数量之间呈负相关。因此,投射的纤维密度可能对所形成突触接触的实际形态至关重要。

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