Droge M H, Tao Y
Department of Biology, Texas Woman's University, Denton 76204.
Neurosci Lett. 1993 Aug 20;158(2):139-42. doi: 10.1016/0304-3940(93)90248-j.
Bath applications of glycine typically inhibited electromyogram (EMG) activity in the gastrocnemius (G) and tibialis anterior (TA) muscles of neonatal mice, in vitro. Although rhythmic bursting occurred in response to glycine administration, cycle alternation between individual EMG bursts in G and TA muscles was not observed. That strychnine (a glycine 1 receptor antagonist) and cycloleucine (a glycine 2 receptor antagonist) could evoke motor rhythm, when given separately or in combination, confirms that glycine transmission is not required for motor pattern generation in mice. Strychnine application resulted in synchronized EMG bursting in G and TA muscles, suggesting that glycine 1 receptor activation does provide some reciprocal inhibition between the G and TA motor nuclei.
在体外实验中，向新生小鼠的腓肠肌（G）和胫前肌（TA）进行甘氨酸浴式给药通常会抑制其肌电图（EMG）活动。尽管给予甘氨酸后会出现节律性爆发，但未观察到G肌和TA肌中单个EMG爆发之间的周期交替。单独或联合给予士的宁（一种甘氨酸1受体拮抗剂）和环亮氨酸（一种甘氨酸2受体拮抗剂）可诱发运动节律，这证实了甘氨酸传递对于小鼠运动模式的产生并非必需。应用士的宁会导致G肌和TA肌中EMG爆发同步，这表明甘氨酸1受体的激活确实在G运动核和TA运动核之间提供了一些相互抑制作用。
