Ferrer I, Zújar M J, Rivera R, Soria M, Vidal A, Casas R
Unidad de Neuropatología, Hospital Príncipes de España, Universidad de Barcelona, Hospitalet de Llobregat.
Neurosci Lett. 1993 Aug 20;158(2):163-6. doi: 10.1016/0304-3940(93)90254-i.
Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lobe was carried out for diagnostic and counselling purposes. These findings suggest that, although parvalbumin-immunoreactive cells are relatively resistant to degeneration in Alzheimer's disease, parvalbumin-immunoreactive neuronal processes can degenerate in some cases of Alzheimer's disease.
在两名阿尔茨海默病患者的大脑皮层中发现了与老年斑相关的小白蛋白免疫反应性营养不良神经突和异常终末芽，同时小白蛋白免疫反应性神经元的密度保持不变，其中一名患者有家族病史，为进行诊断和咨询对其左额叶进行了活检。这些发现表明，尽管小白蛋白免疫反应性细胞在阿尔茨海默病中相对抗退变，但在某些阿尔茨海默病病例中，小白蛋白免疫反应性神经元突起可能会发生退变。
