Craig C G, White T D
Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Neurosci Lett. 1993 Aug 20;158(2):167-9. doi: 10.1016/0304-3940(93)90255-j.
Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, L-arginine did not augment and L-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.
兴奋性氨基酸（EAA）如谷氨酸，通过激活NMDA和非NMDA EAA受体，从体外灌流的大鼠皮层切片中释放抑制性神经调质腺苷。本研究探讨了NMDA诱发的腺苷释放可能涉及一氧化氮（NO）中间形成的可能性。然而，硝普钠并未诱发腺苷释放，L-精氨酸并未增强且L-Nv-硝基精氨酸并未减少NMDA诱发的腺苷释放。因此，似乎NMDA诱发的NO形成在皮层中NMDA诱发的腺苷释放中不起作用。
