Kmiot W A, Stonelake P, Sagar G, Donovan I A, Neoptolemos J P, Notghi A, Harding L K
University Department of Surgery, Dudley Road Hospital, Birmingham, UK.
Nucl Med Commun. 1993 Sep;14(9):788-91. doi: 10.1097/00006231-199309000-00008.
Ten patients underwent contrast-enhanced abdominal computed tomographic (CT) carcinoembryonic antigen (CEA) measurement and murine 111In-B72.3 monoclonal antibody radioimmunoscintigraphy for recurrent or residual colorectal carcinoma. All patients had undergone primary colorectal tumour resection at a median of 3 (range 1-18) months previously. Histological analysis of pelvic tissue biopsies confirmed that six patients had recurrent or residual colorectal cancer and that four were tumour free. Whilst scintigraphy correctly showed all six patients with recurrent or residual disease, both CT and CEA measurement were correct in only four patients. In the four patients without recurrent cancer, CT was correct in two patients whilst scintigraphy and CEA measurement were accurate in three patients. Six out of the 10 patients showed marked nonspecific colonic excretion of radiolabelled antibody which was correctly interpreted in five patients. Future prospective studies comparing CT scans, CEA estimation and B72.3 radioimmunoscintigraphy in a larger group of patients with suspected residual or recurrent colorectal adenocarcinoma may help to define the respective sensitivity and specificity of these techniques.
10例患者接受了腹部增强计算机断层扫描（CT）癌胚抗原（CEA）检测以及鼠源性111In - B72.3单克隆抗体放射免疫闪烁显像，以评估复发性或残留性结直肠癌。所有患者此前均接受了原发性结直肠癌肿瘤切除，中位时间为3个月（范围1 - 18个月）。盆腔组织活检的组织学分析证实，6例患者存在复发性或残留性结直肠癌，4例无肿瘤。虽然闪烁显像正确显示了所有6例患有复发性或残留性疾病的患者，但CT和CEA检测仅在4例患者中正确。在4例无复发性癌症的患者中，CT在2例患者中正确，而闪烁显像和CEA检测在3例患者中准确。10例患者中有6例显示放射性标记抗体在结肠有明显的非特异性排泄，其中5例得到了正确解读。未来在更大一组疑似残留或复发性结直肠腺癌患者中比较CT扫描、CEA评估和B72.3放射免疫闪烁显像的前瞻性研究，可能有助于确定这些技术各自的敏感性和特异性。
