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[移植到大脑中的胚胎神经细胞的行为]

[The behavior of embryonic nerve cells transplanted into the brain].

作者信息

Aleksandrova M A, Loseva E V, Ermakova I V

出版信息

Ontogenez. 1993 Sep-Oct;24(5):43-50.

PMID:8233306
Abstract

Small solid pieces of 3H-thymidine labeled rat neocortex at day 20 of embryonic development were transplanted homotopically into the cortex of adult rats. Transplanted cells migrated from the site of implantation into cortical layers 2-4 of the host to the distance of about 1 mm. No labeled neurons was found in cortical layers 5-6 (the target site during their normal migration). Migration of glial cells was similar to that of astrocytes moving from the suspension grafts. In some cases, similar distribution of migrating donor cells around the implantation site was observed despite the fact that a solid grafted tissue was absent.

摘要

在胚胎发育第20天,将3H-胸腺嘧啶标记的大鼠新皮质小固体片同位移植到成年大鼠的皮质中。移植细胞从植入部位迁移到宿主皮质的第2 - 4层,迁移距离约为1毫米。在皮质第5 - 6层(它们正常迁移时的目标部位)未发现标记神经元。胶质细胞的迁移与从悬浮移植物中迁移的星形胶质细胞相似。在某些情况下,尽管没有固体移植组织,但在植入部位周围仍观察到迁移的供体细胞有类似的分布。

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