Dohán O, Góth M, Szabolcs I, Kovács L, Kovács Z, Szilágyi G
I. Belgyógyászati Klinika, Orvostovábbképzö Egyetem.
Orv Hetil. 1993 Oct 17;134(42):2301-3.
Insulin-like growth factor-I (IGF-I) and basal growth hormone (GH) (average of GH values measured at -20 an 0 minutes) levels were measured in 32 (29 treated, 3 untreated) patients with acromegaly. In 15 patients IGF-I and basal GH values were normal. In 12 patients both GH and IGF-I were elevated. In 5 cases normal basal GH and elevated IGF-I levels were found. We assume that elevated serum level of IGF-I is a reliable sign of acromegalic activity. Compared to this, the basal GH level proved to be a much less reliable indicator to predict or exclude active acromegaly (sensitivity: 0.7, specificity: 1, positive predictive value: 1, negative predictive value: 0.75).
在32例（29例接受治疗，3例未治疗）肢端肥大症患者中测量了胰岛素样生长因子-I（IGF-I）和基础生长激素（GH）（-20分钟和0分钟时测量的GH值的平均值）水平。15例患者的IGF-I和基础GH值正常。12例患者的GH和IGF-I均升高。5例患者基础GH正常但IGF-I水平升高。我们认为血清IGF-I水平升高是肢端肥大症活动的可靠标志。相比之下，基础GH水平被证明是预测或排除活动性肢端肥大症的可靠得多的指标（敏感性：0.7，特异性：1，阳性预测值：1，阴性预测值：0.75）。
