Theodos C M, Titus R G
Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115.
Parasite Immunol. 1993 Aug;15(8):481-7. doi: 10.1111/j.1365-3024.1993.tb00634.x.
Previous work from our laboratory demonstrated that the infectivity of the protozoan parasite Leishmania major was enhanced in mice if the infecting inoculum contained salivary gland lysates from the sand fly vector Lutzomyia longipalpis. The present study was designed to address the hypothesis that sand fly salivary gland material may function by inhibiting the host immune response. Results indicated that sand fly saliva inhibited the ability of macrophages to present leishmanial antigens to parasite-specific T cells.
我们实验室之前的研究表明，如果感染接种物中含有来自白蛉传播媒介长须罗蛉唾液腺裂解物，原生动物寄生虫硕大利什曼原虫在小鼠中的感染性会增强。本研究旨在验证白蛉唾液腺物质可能通过抑制宿主免疫反应发挥作用这一假设。结果表明，白蛉唾液抑制了巨噬细胞向寄生虫特异性T细胞呈递利什曼原虫抗原的能力。
