Schrével J, Barrault C, Deguercy A, Grellier P, Lawton P, Heidrich H G, Caballero M, Monsigny M, Mayer R
Laboratoire de Biologie Parasitaire et Chimiothérapie, URA CNRS 114, Muséum National d'Histoire Naturelle, Paris, France.
Parassitologia. 1993 Jul;35 Suppl:103-5.
Malarial proteinases of the erythrocytic life-cycle are used to design new inhibitors capable of blocking the parasite's development. The Merozoite Proteinase for Erythrocytic Invasion (MPEI) of Plasmodium falciparum, a neutral proteinase, and the acidic Pf37 proteinase acting on spectrin as substrate, are good candidates for this kind of strategy.
疟原虫红细胞内生命周期的蛋白酶被用于设计能够阻断寄生虫发育的新型抑制剂。恶性疟原虫的红细胞入侵裂殖子蛋白酶(MPEI,一种中性蛋白酶)以及以血影蛋白为底物的酸性Pf37蛋白酶,是这类策略的良好候选对象。