Siegers C P, Siemers J, Baretton G
Institutes of Toxicology, Medical University of Lübeck, FRG.
Pharmacology. 1993 Oct;47 Suppl 1:205-8. doi: 10.1159/000139859.
In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrotoxicity were observed.
在雄性小鼠二甲基肼诱导的结肠直肠肿瘤模型中，富含芦荟素或番泻苷的饮食（0.03%）在20周后并未促进腺瘤和癌的发生率及生长。此外，在食用蒽醌类物质的小鼠中，未观察到血清电解质以及肝毒性和肾毒性参数有显著变化。
