Harvey I, Ron M A, Du Boulay G, Wicks D, Lewis S W, Murray R M
Institute of Neurology, London.
Psychol Med. 1993 Aug;23(3):591-604. doi: 10.1017/s003329170002537x.
The MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in excess of the loss of volume observed in other areas of the cortex. MRI abnormalities correlated poorly with clinical parameters, although both unemployment and poor pre-morbid adjustment predicted reduced cerebral volume and increased sulcal volume. These results question whether the medial temporal lobes are the only site of structural pathology in schizophrenia.
对48名符合研究诊断标准委员会（RDC）标准的精神分裂症患者的磁共振成像（MRI）扫描结果，与34名在年龄、种族和父母社会阶层相匹配的健康对照者的扫描结果进行了比较。由于皮质体积选择性减少，精神分裂症组的额叶和顶叶前部体积显著减小，脑沟液体积相应增加。颞叶灰质体积减少在右侧更为明显，但未超过在皮质其他区域观察到的体积损失。MRI异常与临床参数相关性较差，尽管失业和病前适应不良均预示着脑体积减小和脑沟体积增加。这些结果质疑了内侧颞叶是否是精神分裂症唯一的结构病理学部位。
