Glazebrook K N, McGrath F P, Steele B T
Department of Radiology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Radiology. 1993 Dec;189(3):733-5. doi: 10.1148/radiology.189.3.8234697.
To determine whether compensatory renal growth (CRG), which occurs in adults, children, and infants after loss of functioning renal tissue, occurs in fetal life.
Prenatal ultrasound scans were used to select 29 patients with a unilateral multicystic dysplastic kidney and four patients with unilateral renal agenesis. Accurate measurements of prenatal renal length were obtained in 21 of these patients; an accurate measurement of postnatal renal length and birth weight was obtained in 27 of these patients. Prenatal and postnatal renal measurements of the contralateral kidney were compared with renal length in 23 matched control patients and previously reported normal renal lengths.
The single functioning kidneys in the study patients were significantly longer than those in the control patients before and after birth (P = .001).
This study provides strong evidence to support the belief that CRG occurs before birth.
确定在成人、儿童和婴儿功能性肾组织丧失后发生的代偿性肾生长（CRG）是否发生在胎儿期。
产前超声扫描用于选择29例单侧多囊性发育不良肾患者和4例单侧肾缺如患者。其中21例患者获得了产前肾长度的准确测量值；27例患者获得了产后肾长度和出生体重的准确测量值。将对侧肾的产前和产后测量值与23例匹配对照患者的肾长度以及先前报道的正常肾长度进行比较。
研究患者的单个功能肾在出生前后均显著长于对照患者（P = .001）。
本研究提供了有力证据支持CRG发生在出生前这一观点。
