Dickerson L W, Huang A H, Thurnher M M, Nearing B D, Verrier R L
Department of Pharmacology, Georgetown University School of Medicine, Washington, D.C. 20007.
Sleep. 1993 Sep;16(6):550-7. doi: 10.1093/sleep/16.6.550.
Previous studies in dogs showed dramatic increases in coronary blood flow associated with episodes of sinus tachycardia during rapid eye movement (REM) sleep. The present study demonstrates that 90% of these surges in heart rate and coronary flow are concentrated during periods of phasic REM sleep and only 10% in tonic REM sleep. Intensely phasic REM was distinguished from moderately phasic REM sleep by the degree of phasic eye movement. The surges were three times more frequent during intensely phasic REM than in moderately phasic REM sleep. However, the magnitudes of heart rate (37% +/- 3%) and coronary flow (25% +/- 3%) surges were unaffected by the specific substage of REM sleep. The incidence of surge events was almost eleven times greater in epochs of phasic REM that also contained a muscle twitch than in those that did not. During REM sleep, muscle twitches accompanying surges were not associated with any additional elevations in coronary flow or myocardial demand. Our data indicate that the sinus tachycardia-associated surges in coronary flow represent integrated autonomic responses intrinsic to phasic periods of REM sleep in dogs.
先前对犬类的研究表明，在快速眼动（REM）睡眠期间，窦性心动过速发作会使冠状动脉血流量急剧增加。本研究表明，这些心率和冠状动脉血流激增的90%集中在REM睡眠的时相期，而在REM睡眠的紧张期仅占10%。强烈时相REM睡眠与中度时相REM睡眠的区别在于时相性眼球运动的程度。强烈时相REM睡眠期间的激增频率比中度时相REM睡眠高出两倍。然而，心率（37%±3%）和冠状动脉血流（25%±3%）激增的幅度不受REM睡眠特定亚阶段的影响。在时相REM睡眠且伴有肌肉抽搐的时段，激增事件的发生率几乎比不伴有肌肉抽搐的时段高出十倍。在REM睡眠期间，伴随激增的肌肉抽搐与冠状动脉血流或心肌需求的任何额外升高均无关联。我们的数据表明，与窦性心动过速相关的冠状动脉血流激增代表了犬类REM睡眠时相期固有的自主神经综合反应。
