Boucsein W, Wendt-Suhl G
Psychopharmacology (Berl). 1976 Aug 17;48(3):303-6. doi: 10.1007/BF00496866.
The action of 20 mg chlordiazepoxide upon two different anxiety-evoking conditions in comparison with a control condition was investigated in a double-blind, placebo controlled study with 90 healthy male students. The Ss were told to expect an electric shock two times as strong under one condition and five times as strong under the other one in relation to a shock they had previously found unpleasant. During the anticipation interval of 20 min duration HR, GSR, respiration rate, and a rating of subjective emotional arousal were continuously recorded. The greatest effects of stress could be observed within the last 2 min of the anticipation interval, while interactions between drug- and stress-conditions occurred only at the beginning of the 20-min interval. Under the strong stress condition chlordiazepoxide showed an anxiety-reducing effect, under the control condition, however, paradoxical effects.
在一项针对90名健康男学生的双盲、安慰剂对照研究中，研究了20毫克氯氮卓对两种不同诱发焦虑状况的作用，并与对照状况进行比较。受试者被告知，在一种状况下预期的电击强度是他们之前觉得不愉快的电击强度的两倍，在另一种状况下是五倍。在持续20分钟的预期间隔期间，持续记录心率、皮肤电反应、呼吸频率以及主观情绪唤起评分。压力的最大影响可在预期间隔的最后2分钟内观察到，而药物和压力状况之间的相互作用仅在20分钟间隔开始时出现。在强压力状况下，氯氮卓显示出抗焦虑作用，然而在对照状况下却出现了矛盾的效果。
