Fong Y, Rosen P P, Brennan M F
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Surgery. 1993 Nov;114(5):902-6.
This study examines the natural history of patients treated for multifocal desmoids at a referral center for sarcomas.
Patients with multifocal desmoids seen at Memorial Sloan-Kettering Cancer Center in the 9-year period between 1982 and 1991 were identified through a prospective sarcoma data base. The clinical histories were reviewed. In addition, tumor estrogen and progesterone receptor status were evaluated by immunohistochemistry.
This rare condition occurred in six (4.8%) of the 124 patients with desmoid tumors and all occurred in premenopausal women. In each instance the tumors were restricted to one anatomic region of the body and no patient had familial polyposis or Gardner's syndrome. When tested immunohistochemically, the tumors displayed no nuclear reactivity for estrogen or progesterone receptors.
Further investigative work must be undertaken before considering routine use of antiestrogen therapy even in this subset of patients with desmoid tumors.
本研究调查了在一家肉瘤转诊中心接受多灶性硬纤维瘤治疗的患者的自然病史。
通过前瞻性肉瘤数据库，识别出1982年至1991年这9年间在纪念斯隆凯特琳癌症中心就诊的多灶性硬纤维瘤患者。回顾了他们的临床病史。此外，通过免疫组织化学评估肿瘤雌激素和孕激素受体状态。
在124例硬纤维瘤患者中，有6例（4.8%）出现了这种罕见情况，且均发生在绝经前女性身上。每例患者的肿瘤都局限于身体的一个解剖区域，且没有患者患有家族性息肉病或加德纳综合征。经免疫组织化学检测，肿瘤对雌激素或孕激素受体无核反应。
即使对于这一亚组硬纤维瘤患者，在考虑常规使用抗雌激素治疗之前，也必须进行进一步的调查研究。
