Kristiansen B E, Tveten Y, Ask E, Knapskog A B, Reiten T, Steen-Johnsen J, Hopen G
A/S Telelab, Laboratorium for medisinsk mikrobiologi, Skien.
Tidsskr Nor Laegeforen. 1993 Sep 30;113(23):2933-7.
Since 1987 we have analysed throat samples from 1,086 healthy contacts of 32 patients with meningococcal disease. The disease-causing strain was found in contacts of 17 out of the 32 patients. 161 (18%) of the contacts carried meningococci, and 30 (3%) of them were carriers of the disease-causing strain as determined by DNA fingerprinting. The carrier strain was eradicated in 29 of these 30 contacts by treatment with rifampicin. No secondary case of meningococcal disease was observed. During the four-year period 1984-87, there were 39 confirmed cases of meningococcal disease, including 12 verified and four suspected secondary cases of meningococcal disease. Therefore identification and eradication of the disease-causing strain seems to prevent secondary cases. A change in the Norwegian recommendations for preventing secondary cases of meningococcal disease should be discussed.
自1987年以来，我们对32例脑膜炎球菌病患者的1086名健康接触者的咽喉样本进行了分析。在32例患者中的17例的接触者中发现了致病菌株。161名（18%）接触者携带脑膜炎球菌，通过DNA指纹图谱测定，其中30名（3%）为致病菌株携带者。这30名接触者中有29名通过利福平治疗清除了携带菌株。未观察到脑膜炎球菌病的二代病例。在1984 - 1987年的四年期间，有39例确诊的脑膜炎球菌病病例，包括12例经证实的和4例疑似的脑膜炎球菌病二代病例。因此，识别和清除致病菌株似乎可预防二代病例。应讨论挪威关于预防脑膜炎球菌病二代病例建议的改变。
