De la Peña A, Baños G, Izaguirre R, Mandoki J J, Fernández J M
Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Hemantología, México, D.F.
Steroids. 1993 Sep;58(9):407-9. doi: 10.1016/0039-128x(93)90079-3.
The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the use of prolame and buame in estrogen therapy could reduce the risk of thrombo-embolic accidents.
描述了雌二醇和合成雌激素（普洛美、布阿美和普罗阿美）对血小板聚集的体外作用。普洛美和布阿美对血小板聚集产生剂量依赖性抑制作用。雌二醇和普罗阿美未显示出抗聚集作用。结果表明，在雌激素治疗中使用普洛美和布阿美可降低血栓栓塞意外的风险。
