Allen S J, Rowe P, Allsopp C E, Riley E M, Jakobsen P H, Hill A V, Greenwood B M
Medical Research Council Laboratories, Fajara, The Gambia, UK.
Trans R Soc Trop Med Hyg. 1993 May-Jun;87(3):282-5. doi: 10.1016/0035-9203(93)90129-e.
The protective effect of alpha thalassaemia (-alpha/alpha alpha) against morbidity from falciparum malaria was assessed in a prospective study of rural Gambian children. The gene frequency for single alpha-globin gene deletions was 0.12. Malariometric indices measured during cross-sectional surveys and morbidity from malaria determined by weekly surveillance were similar in children with alpha thalassaemia and in those with a normal alpha-globin genotype. However, the small number of children who carried both alpha thalassaemia and the sickle cell trait had fewer clinical episodes of malaria than children with the sickle cell trait alone. Specific antibody responses and cell-mediated immune responses in vitro to defined Plasmodium falciparum antigens were measured in children participating in the study. In general, there was no evidence of an increased prevalence or intensity of humoral or cell-mediated immune responses to the malaria antigens studied in children heterozygous for alpha thalassaemia compared with children with a normal alpha-globin genotype.
在一项针对冈比亚农村儿童的前瞻性研究中，评估了α地中海贫血（-α/αα）对恶性疟发病率的保护作用。单α-珠蛋白基因缺失的基因频率为0.12。在横断面调查中测量的疟原虫学指标以及通过每周监测确定的疟疾发病率，在α地中海贫血儿童和α-珠蛋白基因型正常的儿童中相似。然而，同时携带α地中海贫血和镰状细胞性状的少数儿童，其疟疾临床发作次数比仅具有镰状细胞性状的儿童少。在参与该研究的儿童中，测量了体外对特定恶性疟原虫抗原的特异性抗体反应和细胞介导的免疫反应。总体而言，与α-珠蛋白基因型正常的儿童相比，没有证据表明α地中海贫血杂合子儿童对所研究的疟疾抗原的体液或细胞介导免疫反应的患病率或强度增加。
