Kardinal C G, Komorowski R
South Med J. 1976 Sep;69(9):1216-7.
A 50-year-old black man had the signs and symptoms of severe anemia. His bone marrow contained sheets of primitive cells that could only be conclusively identified as being of plasmacytic origin by electron microscopy. These cells produced only a small quantity of kappa light chain but did fluoresce when stained with immunofluorescent antikappa stain. His initial response to chemotherapy was dramatic, but after eight months his condition was refractory to all further attempts at treatment. This case supports the observation of Hobbs that patients with Bence-Jones myeloma may have a poorer prognosis than those with otherwise typical IgG or IgA myeloma.
一名50岁的黑人男性出现了严重贫血的体征和症状。他的骨髓中含有成片的原始细胞，只有通过电子显微镜才能最终确定这些细胞起源于浆细胞。这些细胞仅产生少量的κ轻链，但在用免疫荧光抗κ染色时会发出荧光。他对化疗的初始反应显著，但八个月后，他的病情对所有进一步的治疗尝试均产生耐药。该病例支持了霍布斯的观察结果，即患有本斯·琼斯骨髓瘤的患者预后可能比患有其他典型IgG或IgA骨髓瘤的患者更差。
