Eddi C, Bianchin I, Honer M R, Muniz R A, Caracostantogolo J, do Nascimento Y A
Instituto de Patobiologia CICV-INTA, CC77-1708 Moron, Argentina.
Vet Parasitol. 1993 Jul;49(1):39-44. doi: 10.1016/0304-4017(93)90221-8.
Two studies were conducted, one in Argentina and one in Brazil, to evaluate the therapeutic efficacy of doramectin administered subcutaneously at a dose rate of 200 micrograms kg-1 (1 ml per 50 kg) to cattle harboring mixed field infections of gastrointestinal nematodes. In each trial, 20 heifers were randomly allocated to a control or treated group of ten animals each, on the basis of fecal egg counts. Animals in the treated and control groups received an injection of doramectin or saline in the lateral midline of the neck. From 14 to 18 days post-treatment an equal number of animals from each group were slaughtered every day and the worm burdens of doramectin-treated animals were compared with those of non-treated controls. The efficacy of doramectin was at least 99.9% against adult stages of Ostertagia ostertagi, Haemonchus placei, Haemonchus contortus, Haemonchus similis, Trichostrongylus axei, Cooperia pectinata, Cooperia spatulata, Cooperia surnabada (Cooperia mcmasteri), Oesophagostomum radiatum and Dictyocaulus viviparus. Efficacy against Nematodirus helvetianus was 97.9% while efficacy against Trichuris discolor was 92.3%. Activity against inhibited larval forms of Ostertagia ostertagi, H. placei, Oesophagostomum radiatum, and Trichostrongylus axei, was at least 99.9%.
开展了两项研究，一项在阿根廷，一项在巴西，以评估皮下注射剂量为200微克/千克（每50千克1毫升）多拉菌素对感染胃肠道线虫混合野外感染的牛的治疗效果。在每项试验中，根据粪便虫卵计数，将20头小母牛随机分为每组10只动物的对照组或治疗组。治疗组和对照组的动物在颈部外侧中线接受多拉菌素或生理盐水注射。在治疗后14至18天，每天从每组宰杀相同数量的动物，并将多拉菌素治疗动物的虫负荷与未治疗的对照组进行比较。多拉菌素对奥氏奥斯特线虫、牛血矛线虫、捻转血矛线虫、似血矛线虫、艾氏毛圆线虫、栉状库珀线虫、匙状库珀线虫、苏氏库珀线虫（麦克马斯特库珀线虫）、辐射食道口线虫和胎生网尾线虫成虫阶段的疗效至少为99.9%。对瑞士细颈线虫的疗效为97.9%，对变色毛首线虫的疗效为92.3%。对奥氏奥斯特线虫、牛血矛线虫、辐射食道口线虫和艾氏毛圆线虫抑制性幼虫形态的活性至少为99.9%。
