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猪补体激活片段C3c和C3d的分离及其在单特异性抗体制备中的应用。

Isolation of the porcine complement activation fragments C3c and C3d and their use in the preparation of monospecific antibodies.

作者信息

Storm K E, Nilsson U R

机构信息

Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.

出版信息

Vet Immunol Immunopathol. 1993 Aug;37(3-4):231-41. doi: 10.1016/0165-2427(93)90196-b.

DOI:10.1016/0165-2427(93)90196-b
PMID:8236800
Abstract

The hemolytic test to date has been the sole analytic technique applied to study the complement reaction in the swine. To improve the analytical possibilities for this species we have developed polyclonal antibody reagents with specificities for the C3c and C3d activation fragments of swine C3. Access to these reagents, by which activation products can be analysed in tissues and biological fluids, will offer new possibilities for a more precise analysis of the complement reaction.

摘要

迄今为止，溶血试验一直是用于研究猪体内补体反应的唯一分析技术。为了提高对该物种的分析可能性，我们开发了针对猪C3的C3c和C3d激活片段具有特异性的多克隆抗体试剂。通过这些试剂可以在组织和生物体液中分析激活产物，这将为更精确地分析补体反应提供新的可能性。

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