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子宫复发性透明细胞平滑肌瘤(作者译)

[Recurring clear cell leiomyoblastoma of the uterus (author's transl)].

作者信息

Dallenbach-Hellweg G, Epple H, Birovljev P, Fischbach H

出版信息

Virchows Arch A Pathol Anat Histol. 1976 Sep 21;371(3):243-50. doi: 10.1007/BF00433071.

Abstract

We report on the clinical and pathologic manifestations of an unusual myometrial tumor that developed in a woman now 52 years old. Fifteen years before, she had been operated on for a "leiomyoma" of the uterus. On re-operation 9 years later and again 4 years later a clear cell leiomyoma of the uterus was resected but each time it appeared histologically benign. A third local recurrence of the tumor 7 months later necessitated a fourth operation. The tumor was then found to be invasive, preventing total excision, and histologically was malignant as the striking cellular pleomorphism suggested. As far as we know, only two similar cases have been reported in the literature, but these were diagnosed as benign and followed for only short periods. The discrepancy between the benign histologic picture of this tumour and its biological behavior pose problems in treatment which are discussed.

摘要

我们报告了一名52岁女性所患的一种罕见子宫肌层肿瘤的临床和病理表现。15年前,她因子宫“平滑肌瘤”接受了手术。9年后再次手术,4年后又进行了一次手术,切除了子宫透明细胞平滑肌瘤,但每次组织学检查均显示为良性。7个月后肿瘤第三次局部复发,需要进行第四次手术。此时发现肿瘤具有侵袭性,无法完全切除,而且组织学检查显示为恶性,因为明显的细胞多形性表明了这一点。据我们所知,文献中仅报道了两例类似病例,但这些病例均被诊断为良性,且随访时间较短。本文讨论了该肿瘤组织学表现为良性与其生物学行为之间的差异所带来的治疗问题。

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