Cho K R, Woodruff J D, Epstein J I
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21205.
Hum Pathol. 1989 Jan;20(1):80-3. doi: 10.1016/0046-8177(89)90207-4.
A 17-year-old woman underwent hysterectomy for removal of a "mitotically active" (six to seven mitoses per 10 high-power fields) yet otherwise benign-appearing cellular smooth muscle tumor. Eleven years later, she developed multiple histologically benign smooth muscle tumors in the posterior mediastinum, deep soft tissues of the neck, paravertebral region, incisional scar, and mesentery. The distribution and histologic appearance of the tumors, as well as the protracted clinical course, suggest multifocal origin rather than widespread metastases from a low-grade uterine leiomyosarcoma. This case raises the possibility that some similar cases reported as so-called benign metastasizing leiomyoma may be more satisfactorily explained by the concept of multifocality.
一名17岁女性因切除一个“有丝分裂活跃”（每10个高倍视野中有6至7个有丝分裂象）但外观良性的细胞性平滑肌瘤而接受了子宫切除术。11年后，她在后纵隔、颈部深部软组织、椎旁区域、手术切口瘢痕和肠系膜出现了多个组织学上良性的平滑肌瘤。肿瘤的分布和组织学表现，以及病程迁延，提示为多灶起源，而非低级别子宫平滑肌肉瘤的广泛转移。该病例提示，一些被报道为所谓良性转移性平滑肌瘤的类似病例，可能用多灶性概念能得到更满意的解释。
