Heinz G
Abteilung für Kardiologie, Universitätsklinik für Innere Medizin II, Wien.
Wien Klin Wochenschr. 1993;105(19):535-43.
The sick sinus syndrome after cardiac transplantation is a new entity characterized by impaired automaticity (bradycardia, pathologic function tests, latent sinus node dysfunction) or entire lack of sinus activity (junctional escape mechanism), while the sinus node refractoriness and AV nodal function is usually unaffected. It may significantly affect quality of life after cardiac transplantation. Postoperative sinus node dysfunction is usually transient. However, patients in whom sinus rhythm has not been established by the fourth postoperative week should undergo pacemaker placement, given the unreliability of escape mechanisms in the denervated state. Patients with a latent type of sinus node dysfunction are likewise at risk of developing severe symptoms. These patients who usually are not prophylactically supplied with a pacemaker, may benefit from aminophylline therapy.
心脏移植后病态窦房结综合征是一种新的病症，其特征为自律性受损（心动过缓、病理功能检查、潜在窦房结功能障碍）或完全缺乏窦性活动（交界性逸搏机制），而窦房结不应期和房室结功能通常不受影响。它可能会显著影响心脏移植后的生活质量。术后窦房结功能障碍通常是短暂的。然而，鉴于去神经状态下逸搏机制的不可靠性，术后第四周仍未建立窦性心律的患者应接受起搏器植入。潜在型窦房结功能障碍患者同样有出现严重症状的风险。这些通常未预防性植入起搏器的患者可能从氨茶碱治疗中获益。
