Hara T, Komiyama T, Yokoi F
National Nakano Chest Hospital, Tokyo, Japan.
Yakubutsu Seishin Kodo. 1993 Jun;13(3):175-81.
We synthesized 11C-labeled (R)nicotine (11C: a positron-emitting radioisotope with a half-life of 20 min, produced in a cyclotron), and utilized it for blood flow measurement in the human brain. The positron emission tomography was employed for the data acquisition and image reconstruction. The behavior of the isotope was formulated by a mathematical model, consisting of a blood compartment and a tissue compartment, and the time-activity curve in various parts of the brain was analyzed in a computer to obtain a mathematically simulated curve which fell in consistence with both the arterial blood curve and the brain curve. The cerebral blood flow (CBF) value thus determined was compared with the value obtained by the standard C15O2 inhalation method (= H2(15)O method). The nicotine method always gave a higher value than the standard method by 27-34%. It seems that CBF determined by the 11C-(R)nicotine method is more accurate than the value determined by the standard method, because our tracer is superior as a CBF indicator to radiolabeled water.
我们合成了11C标记的（R）尼古丁（11C：一种半衰期为20分钟的正电子发射放射性同位素，由回旋加速器产生），并将其用于人体大脑的血流测量。采用正电子发射断层扫描进行数据采集和图像重建。该同位素的行为由一个数学模型来描述，该模型由一个血液隔室和一个组织隔室组成，通过计算机分析大脑各部位的时间-活性曲线，以获得与动脉血曲线和大脑曲线均相符的数学模拟曲线。将如此确定的脑血流量（CBF）值与通过标准C15O2吸入法（=H2(15)O法）获得的值进行比较。尼古丁法得出的值总是比标准法高27%-34%。看来，用11C-（R）尼古丁法测定的CBF比用标准法测定的值更准确，因为我们的示踪剂作为CBF指示剂优于放射性标记水。
